Understanding GDFs and Their Receptors in Cellular Signaling Growth differentiation factors (GDFs) play crucial roles in numerous biological processes, from embryonic development to tissue homeostasis. As members of the TGF-β superfamily, these signaling molecules mediate essential cellular communications through specific receptor interactions. Key Features of GDF Signaling: • Diverse Biological Functions : GDFs regulate cell growth, differentiation, and tissue morphogenesis • Precise Receptor Binding : Specific interactions with type I and type II serine/threonine kinase receptors • Downstream Pathway Activation : SMAD-dependent and independent signaling cascades • Therapeutic Potential : Emerging targets for musculoskeletal disorders, metabolic diseases, and cancer Research Applications: Musculoskeletal development studies Metabolic regulation research Reproductive biology investigations Wound healing and fibrosis models Our comprehensive res...